Capecitabine (Xeloda), a chemotherapy medication used to treat various cancers, can bring about uncomfortable side effects such as Palmar Plantar Erythrodysesthesia (PPE) and neuropathy. PPE is also known as a potential side effect with Doxorubicin, cytarabine, docetaxel and fluorouracil therapy. These conditions can significantly impact a patient's quality of life during treatment and potentially halt the ongoing use of the chemotherapy if symptoms become severe. However, with proactive measures and the right interventions, managing these potential side effects becomes more feasible.
Palmar Plantar Erythrodysesthesia (PPE) is also known as hand-foot syndrome, primarily affects the palms of the hands and the soles of the feet, causing a range of symptoms that can impact a patient’s daily activities.
Symptoms of PPE:
PPE symptoms can vary in severity and may include:
Redness and Swelling: The affected areas often become red and swollen.
Pain and Tenderness: Patients may experience a burning sensation, tenderness, or pain in the hands and feet.
Blistering and Peeling: In severe cases, the skin may blister, peel, or develop painful sores.
Numbness and Tingling: Some patients report numbness or a tingling sensation in the affected areas.
Cracking and Fissures: The skin may crack or develop fissures, leading to potential infection if not properly managed.
Preventive Measures Before Capecitabine Treatment:
Before starting Capecitabine or one of the other chemotherapies associated with PPE, it's essential to prepare your hands and feet. A gentle pedicure and manicure can help tidy up nails and cuticles. Moisturizing with products like BioFirst Skin Saver Cream, Moo Goo Moisturizer, or Coconut Oil can help maintain skin hydration. Additionally, ensure your footwear is comfortable and doesn't cause irritation. Soft woollen socks or loose-fitting slippers can be beneficial, especially at home.
Preventing PPE During Treatment:
Once treatment begins, taking preventive measures against PPE becomes crucial. Here are some effective strategies.
Complementary Medicines:
1. Vitamin B6: Taking the appropriate dose daily may help alleviate symptoms.
Nitric Oxide Precursors: Taken daily has been shown to alleviate the symptoms, this may be used more frequently depending on PPE severity.
3. Acupuncture: Seek treatment from a practitioner experienced in managing chemotherapy-induced PPE.
4. White Vinegar Soaks: Diluted white vinegar can help soothe skin and prevent further complications if splitting or wounds develop.
5. Explore Other Therapies: Inquire about additional options such as Henna, Vitamin E, Saffron and other emerging natural therapies supported by research in your next PROSPER Cancer Care appointment.
OTC & Pharmaceutical Support:
1. UREA Eulactol Heel Balm: Apply twice daily to hands and feet to help prevent skin dryness and cracking.
2. Topical Viagra Cream: Consult with your oncologist about the possibility of using compounded topical Viagra cream, as suggested by recent studies.
Managing Neuropathy Associated with PPE:
Neuropathy, characterized by nerve pain, often worse for variation in temperatures, is another potential side effect of chemotherapy and PPE. Here are some strategies to alleviate neuropathic symptoms:
1. Cold Water Swimming: Immersion in cold water may provide temporary relief from neuropathic pain.
2. Cold Ice Socks and Gloves: Consider using specialized cold therapy products to alleviate discomfort, these are commercially available to take along to wear during your treatment for neuropathy suffered during IV chemotherapy.
3. Voltaren Anti-inflammatory Gel: Topically applying Voltaren gel can help reduce burning heat pain associated with neuropathy.
4. PEA (Palmidrol - palmitoylethanolamide): Taken daily PEA can help manage neuropathic pain and is a very effective anodyne and neuro anti-inflammatory, research evident complementary medicine.
Communication with Healthcare Providers:
If you experience PPE, discomfort, or neuropathic pain while undergoing treatment that is progressively worsening, it is essential to communicate these issues with your oncologist during your next appointment. Adjusting the dosage or exploring additional interventions may be necessary to ensure your comfort and well-being.
Managing chemotherapy-induced PPE and neuropathy requires a proactive approach involving preventive measures, symptom management strategies, and open communication with healthcare providers. By seeking advice and implementing the recommended interventions, people undergoing treatment can better navigate the challenges associated with chemotherapy side effects, ultimately enhancing their treatment experience and quality of life.
This article is intended to be informational only and represents the opinion of the author. It is not intended to be used as medical advice and does not take the place of advice from a qualified health care practitioner in a clinical setting. Please check with your healthcare practitioner before embarking upon any of the treatments discussed.
